Manny Pacquiao returns to the ring after a two-year layoff when he takes on WBA welterweight titleholder Yordenis Ugas. The 42-year-old Pacquiao is regarded as one of the greatest professional boxers of all time. He is the only eight-division world champion, winning 12 major world titles, and is the only boxer to hold world championships across four decades.

The pay per view title fight tops the main card which is scheduled to begin at 9 p.m. ET from T-Mobile Arena in Las Vegas, with the headliners expected to start at 11:30 p.m. ET. Pacquiao is a -360 favorite (risk $360 to win $100), while Ugas is priced at +280 (risk $100 to win $280) in the latest Pacquiao vs. Ugas odds from Caesars Sportsbook. The over-under for total rounds expected is set at 10.5.

Before making any picks for Pacquiao vs. Ugas, you NEED to see the predictions from SportsLine combat sports expert Brandon Wise. 

In fact, Wise called Israel Adesanya by decision at +140 and Brandon Moreno to win outright at +190 at UFC 263 earlier this summer. Wise went a perfect 5-0 at UFC 239 and was 4-1 at both UFC 245 and UFC 249.

He also nailed Khabib Nurmagomedov's destruction of Conor McGregor in 2018, Stipe Miocic's defeat of Daniel Cormier, Max Holloway's downfall in 2019 and Justin Gaethje's TKO victory over Tony Ferguson in May of last year. Anyone who has followed Wise's combat sports selections is WAY UP! 

For Pacquiao vs. Ugas, we can tell you Wise likes the fight to go Over 10.5 rounds, but he has a much more confident play on a method of victory prop that returns plus money! You ABSOLUTELY need to see Wise's picks before making any of your own!

Who wins Pacquiao vs. Ugas on Saturday? ... Join SportsLine here to see which bets you need to make for Saturday's big fight, all from the accomplished combat sports analyst who has been profitable every year!