The No. 16 LSU Tigers will look to continue their dominance over the South Carolina Gamecocks when they meet in a key SEC matchup on Saturday. LSU has won the last seven meetings with South Carolina and is 19-2-1 all-time against the rivals. The Tigers (1-1), who were just 2-2 on the road last year, finished 10-3 overall in 2023. The Gamecocks (2-0), who were 5-2 at home, won just three of eight conference games a season ago.

Kickoff from Williams-Brice Stadium in Columbia, S.C., is set for noon ET. The Tigers are favored by 6.5 points in the latest LSU vs. South Carolina odds, while the over/under for total points scored is 48. You'll want to see the FBS college football predictions from the SportsLine Projection Model before laying any LSU vs. South Carolina picks down.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season! Anyone who has followed it has seen strong returns.

The model has simulated LSU vs. South Carolina 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread is the better value.

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