The Loyola Chicago Ramblers and Saint Louis Billikens will jockey for positioning in the Atlantic 10 standings when they meet on Friday night. Loyola Chicago has won three of its last four games, including an 87-80 win in overtime at Richmond on Tuesday. Saint Louis has lost three of its last four outings, falling to George Mason in overtime earlier this week.  

Tipoff is set for 7 p.m. ET on Friday at Gentile Arena. Loyola Chicago is favored by 2.5 points in the latest Loyola Chicago vs. Saint Louis odds, while the over/under is 140.5 points, per SportsLine consensus. Before entering any Saint Louis vs. Loyola Chicago  picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 15 of the 2024-25 season on a 211-154 betting roll (+2024) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Loyola Chicago vs. Saint Louis 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Loyola Chicago vs. Saint Louis? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.