The Louisville Cardinals will battle the West Virginia Mountaineers in a Battle 4 Atlantis semifinal matchup on Thanksgiving Day. Louisville advanced with an 89-61 thrashing of 14th-ranked Indiana on Wednesday, while West Virginia rallied for an 86-78 overtime win over third-ranked Gonzaga in their first-round matchup. The Cardinals (4-1), who finished 15th in the Atlantic Coast Conference at 3-17 and were 8-24 overall a year ago, have won three in a row. The Mountaineers (4-1), who tied with Oklahoma State for 13th in the Big 12 at 4-14 and were 9-23 overall in 2023-24, are riding a two-game winning streak.

Tip-off from Imperial Arena at Paradise Island, Bahamas is set for noon ET. The Cardinals are 2.5-point favorites in the latest Louisville vs. West Virginia odds from SportsLine consensus, while the over/under for total points scored is set at 151. Louisville is the -142 money line favorite (risk $142 to win $100), while West Virginia is the +120 underdog. Before entering any Louisville vs. West Virginia picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 4 of the 2024-25 season on a 162-118 roll (+1952) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Louisville vs. West Virginia 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting well over 60% of the time!

So who wins Louisville vs. West Virginia, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!