The No. 15 Louisville Cardinals (10-3) will look to secure their first 11-win season since Charlie Strong did it back-to-back in 2012 and 2013, but they'll have to go through the USC Trojans (7-5) at the 2023 Holiday Bowl to do it. It was a disappointing season for USC and former Heisman Trophy winner Caleb Williams has opted out of the bowl game to begin prep for the 2024 NFL Draft. However, Lincoln Riley's squad will still be seeking a crucial win to start building momentum for a move to the Big Ten next season.

Kickoff is set for 8 p.m. ET on Wednesday at Petco Park in San Diego, Calif. The Cardinals are favored by 7 points in the latest Louisville vs. USC odds, while the over/under is 59 points, per SportsLine consensus. Before entering any USC vs. Louisville picks, you NEED to see the college football predictions from the model at SportsLine.

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The model has simulated Louisville vs. USC 10,000 times and the results are in. We can tell you that the model is leaning Over and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the pick at SportsLine.

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