The Louisville Cardinals begin their 2021 season with a matchup against Ole Miss in Atlanta. Kickoff from Mercedes-Benz Stadium is set for 8 p.m. ET. Louisville finished the 2020 season with a 4-7 record. Four of those losses were by seven or fewer points, so there is hope for them to make a turnaround this year. 

Lane Kiffin and his high-powered offense led by junior quarterback Matt Corral averaged 39 points a game in 2020. The Rebels still only finished with a 5-5 record. Kiffin will miss this matchup after testing positive for COVID-19 over the weekend. Ole Miss is favored by nine points in the latest odds from Caesars Sportsbook, while the Over-Under is set at 74.5.

Before you make any Louisville vs. Ole Miss picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Louisville vs. Ole Miss 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. Ole Miss? And which side of the spread hits almost 60 percent of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!