The No. 16 Notre Dame Fighting Irish are set to host the No. 15 Louisville Cardinals on Saturday afternoon. The Fighting Irish are coming off a comfortable 28-3 victory over Miami (OH), while the Cardinals secured an impressive 31-19 win over Georgia Tech in their last outing. 

Kickoff from Notre Dame Stadium is set for 3:30 p.m. ET. The Fighting Irish are 6.5-point favorites according to the latest Louisville vs. Notre Dame odds via SportsLine consensus, while the over/under for total points scored is 46. 

Before entering any Notre Dame vs. Louisville picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

The model knows the Fighting Irish are led by their suffocating defense. Notre Dame is giving up just 9.75 points per game this season, which ranks 10th in the nation. In last week's victory over Miami (OH), Notre Dame gave up only three points and held RedHawks quarterback Brett Gabbert to just 119 passing yards. 

The model has also taken into account that Louisville is extremely explosive on offense, averaging 47.3 points per game, which ranks 12th in the country. Louisville is led by quarterback Tyler Shough, who's completing 68.4% of his passes for 850 yards, eight touchdowns and zero interceptions.

For Saturday, the model has set its sights on Louisville vs. Notre Dame. We can tell you it is leaning Over the total, projecting a combined 50 points. It also says one side of the spread hits in nearly 60% of simulations. You ABSOLUTELY need to see it before locking in any college football picks.

So who wins Notre Dame vs. Louisville, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is up more than $2,000 on top-rated CFB spread picks!