The No. 14 Indiana Hoosiers meet the Louisville Cardinals in the opening game of the Battle 4 Atlantis on Thursday. Indiana is coming off a 69-58 win over North Carolina Greensboro last Thursday, while Louisville defeated Winthrop 76-61 on Friday. The Cardinals (3-1), who finished 15th in the Atlantic Coast Conference at 3-17 and were 8-24 overall a year ago, are 0-3 on neutral courts since the start of 2023-24. The Hoosiers (4-0), who tied for sixth in the Big Ten at 10-10 and were 19-14 overall, are 3-3 on neutral courts since the beginning of last season.

Tip-off from Imperial Arena at Paradise Island, Bahamas is set for noon ET. Indiana leads the all-time series 12-9, including a 4-3 edge in games played on neutral courts. The Hoosiers are 2.5-point favorites in the latest Louisville vs. Indiana odds from SportsLine consensus, while the over/under for total points scored is set at 153.5. Before entering any Louisville vs. Indiana picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 4 of the 2024-25 season on a 162-118 roll (+1952) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Louisville vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting nearly 70% of the time!

So who wins Louisville vs. Indiana, and which side of the spread hits nearly 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!