The 14th-seeded Lipscomb Bisons will battle the third-seeded Iowa State Cyclones in a South Regional first-round matchup on Friday afternoon. The Bisons (25-9), who are making their second NCAA Tournament appearance, will look to become the first Atlantic Sun team to advance to the second round since Liberty in 2019. The Cyclones (24-9), who are making their 24th NCAA Tournament appearance, advanced to the Sweet 16 last year for the seventh time in program history. Injuries have hurt the Cyclones as senior guard Keshon Gilbert has been ruled out for the rest of the season with a muscle strain, while junior guard Tamin Lipsey is expected to play despite dealing with a groin injury.

Tipoff from Fiserv Forum in Milwaukee is set for 1:30 p.m. ET. Iowa State is a 14.5-point favorite in the latest Lipscomb vs. Iowa State odds from SportsLine consensus, while the over/under for total points scored is 143.5. 

Before making any Lipscomb vs. Iowa State picks, check out the college basketball predictions from the SportsLine Projection Model.    

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Lipscomb vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits more than 50% of the time!

So who wins Lipscomb vs. Iowa State, and which side of the spread hits more than 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!