The Detroit Lions (13-2) and the San Francisco 49ers (6-9) are set to end Week 17 when they clash on Monday Night Football. The Lions got back in the win column, defeating the Chicago Bears 34-17 last Sunday. The 49ers have already been eliminated from playoff contention and dropped two straight games. Last week, the Miami Dolphins beat San Francisco 29-17.

Kickoff from Levi's Stadium in San Francisco is set for 8:15 p.m. ET. The Lions are 3.5-point favorites in the latest Lions vs. 49ers odds from the SportsLine Consensus, while the over/under for total points scored is 50.5. The Lions are -182 money-line favorites, while the 49ers are +152 underdogs. 

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The model has simulated Lions vs. 49ers 10,000 times and the results are in. We can tell you the model is leaning Over the point total, and it also says one side of the spread cashes in OVER 50% of simulations!

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