The Denver Nuggets are set to host the Los Angeles Lakers in a key Western Conference rivalry game at Ball Arena on Saturday. The Nuggets are 37-19 overall, and 20-8 at home, while the Lakers are 33-21 overall, and 14-14 on the road this season. Denver won its first game back from the All-Star break, dominating the Charlotte Hornets 129-115 behind another stellar performance from Nikola Jokic. The Lakers are looking to build off their 110-102 win over the Portland Trail Blazers. Luka Doncic (calf) and LeBron James (foot) are probable for the Lakers. 

Tipoff in Denver is at 8:30 p.m. ET. The Nuggets are favored by 6.5 points in the latest Nuggets vs. Lakers odds via SportsLine consensus, and the over/under is 243.5 points. 

Before locking in any Nuggets vs. Lakers picks, you'll want to see the NBA predictions and betting advice from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the second half of the 2024-25 NBA season on a sizzling 147-104 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 18-9 (67%) on top-rated spread picks this season. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Nuggets vs. Lakers 10,000 times and the results are in. We can tell you that the model is leaning Under on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

So who wins Lakers vs. Nuggets, and  which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks!