The No. 3 seed New York Knicks will try to begin a playoff run when they face the No. 6 seed Detroit Pistons in the first round of the 2025 NBA Playoffs on Saturday night. New York lost three of its final four games in the regular season, but it still finished in third place in the Eastern Conference. Detroit also struggled down the stretch of the regular season, losing six of its final eight games. 

Tipoff from Madison Square Garden in New York is set for 6 p.m. ET. The Knicks are 7-point favorites in the latest Knicks vs. Pistons odds via SportsLine consensus, while the over/under for total points scored is 220.5. The Knicks are -297 on the money line (risk $297 to win $100), while the Pistons are +238 (risk $100 to win $238). 

Before making any Pistons vs. Knicks picks, check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters the 2025 NBA playoffs on a sizzling 156-115 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. Anyone following could have seen HUGE returns!

The model has simulated Knicks vs. Pistons 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits well over 50% of the time!

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