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Knicks vs. Lakers odds, line, spread: 2025 NBA picks, March 6 predictions from proven model

SportsLine's model has locked in its best bets for Thursday's game between the New York Knicks and Los Angeles Lakers

By@SportsLinePublished: Mar 07, 2025 12:35AM UTC . 2 min read

The Los Angeles Lakers look to extend their winning streak to eight games when they take on the New York Knicks in a key interconference matchup on Thursday night. New York is coming off a 114-102 loss to the Golden State Warriors on Tuesday, while Los Angeles defeated New Orleans 136-115 that same night. The Knicks (40-21), who have won three of their last four games, are 19-10 on the road this season. The Lakers (39-21), the second seed in the West, are 24-7 on their home floor. OG Anunoby (thumb) and Mitchell Robinson (ankle) are questionable for New York, while LeBron James (foot) and Luka Doncic (knee) are probable for L.A.

Tip-off from Crypto.com Arena in Los Angeles is set for 10 p.m. ET. L.A. won the lone matchup earlier this season, which came on the road. The Lakers are 2.5-point favorites in the latest Knicks vs. Lakers odds from SportsLine consensus, while the over/under for total points scored is 230.5. L.A. is at -144 on the money line (risk $144 to win $100), with New York at +121 (risk $100 to win $121). Before making any Knicks vs. Lakers picks, check out the NBA predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 20 of the 2024-25 NBA season on a sizzling 147-107 roll on all top-rated NBA picks dating back to last season, returning nearly $4,000. It's also an outstanding 18-10 (64%) on top-rated spread picks this season. Anyone following could have seen HUGE returns!

The model has simulated Knicks vs. Lakers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

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