The third-seeded Kentucky Wildcats will take on the second-seeded Tennessee Volunteers in an all-SEC Midwest Region Sweet 16 matchup on Friday. The Wildcats (24-11), who are 134-56 in 64 NCAA Tournaments all-time, have not reached a Final Four since 2015, their second-longest drought ever. The Volunteers (29-7), who are 30-27 in 28 previous tournament appearances, have never made it to the Final Four.

Tip-off from Lucas Oil Stadium in Indianapolis is set for 7:39 p.m. ET. Tennessee is a 4.5-point favorite in the latest Kentucky vs. Tennessee odds from SportsLine consensus, while the over/under for total points scored is 144.5. 

Before making any Kentucky vs. Tennessee picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-168 roll (+1815) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and has nailed 25 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Kentucky vs. Tennessee 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread cashes in well over 50% of simulations!

So who wins Kentucky vs. Tennessee, and which side of the spread cashes in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-168 (+1815) on top-rated college basketball pick and has nailed 25 first-round upsets by double-digit seeds!