The No. 5 Kentucky Wildcats will host the Louisville Cardinals in a rivalry game on Saturday evening. Kentucky has won nine of its first 10 games this season under head coach Mark Pope, including a 78-67 win over Colgate on Wednesday. Louisville snapped a three-game losing streak with a 77-74 win over UTEP on Wednesday, but it failed to cover the spread for the fourth straight game.  

Tipoff is set for 5:15 p.m. ET on Saturday at Rupp Arena. Kentucky is favored by 11.5 points in the latest Kentucky vs. Louisville odds, while the over/under is 156.5 points per SportsLine consensus. Before entering any Louisville vs. Kentucky picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It entered Week 6 of the 2024-25 season on a 174-125 roll (+2196) on all top-rated college basketball picks dating back to 2023. Anyone following has seen HUGE returns!

The model has simulated Kentucky vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. 

So who wins Kentucky vs. Louisville? And which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.