The Kansas Jayhawks and the Texas Southern Tigers are set to square off in a first round matchup in the Midwest Region of the 2022 NCAA Tournament bracket at 9:57 p.m. ET on Thursday, Mar. 17. Kansas locked up a No. 1 seed after capturing the Big 12 Conference Tournament crown, while 16-seed Texas Southern won the SWAC tournament title, then defeated Texas A&M-CC in a First Four matchup on Tuesday night. 

Kansas is favored by 21.5 points in the latest Texas Southern vs. Kansas odds from Caesars Sportsbook, while the Over-Under is set at 145.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Kansas vs. Texas Southern picks or March Madness bets, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Kansas has one of the best players in college basketball in guard Ochai Agbaji, who averages 19.7 points, 5.1 rebounds and 1.6 assists per game. The model is projecting another big night from Agbaji against Texas Southern, with the 6-foot-5 senior projected to score 19 points and pull down six rebounds. The model is calling for a total of six players -- five from Kansas and one from Texas Southern -- to reach double digits in scoring in this first round matchup. 

The model also knows that Kansas ranks 25th in the country in points scored per game (78.6), 18th in field goal percentage (48.1%), and 81st in 3-point field goal percentage (35.5%). Meanwhile, Texas Southern ranks 221st in college basketball in points per game (69.2), 206th in field goal percentage (43.7%), and 280th in 3-point field goal percentage (31.6%).

Now, the model has set its sights on Kansas vs. Texas Southern. We can tell you the model is leaning Under on the point total, and it also says one side of the spread hits in almost 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks of your own.

Who wins Texas Southern vs. Kansas? And which side of the spread hits in almost 60 percent of simulations? ... Join SportsLine right now to find out which side of the Kansas vs. Texas Southern spread you should be all over Thursday, all from the model on a roll on college basketball picks!