The New York Jets and San Francisco 49ers will meet on Monday Night Football to conclude the Week 1 NFL schedule. This will be the first game for Aaron Rodgers with the Jets since he tore his Achilles in the first game last year. Meanwhile, the 49ers fell short to the Kansas City Chiefs in the Super Bowl. Kickoff from Levi's Stadium in San Francisco, Calif., is set for 8:15 p.m. ET. 49ers running back Christian McCaffrey is inactive with a calf injury.

The 49ers are 3.5-point favorites in the latest Jets vs. 49ers odds, while the over/under for total points is 43. The 49ers are -186 money-line favorites (risk $186 to win $100), while the Jets are +155 underdogs (risk $100 to win $155). Before making any Jets vs. 49ers picks, you NEED to see the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 1 of the 2024 NFL season on an incredible 181-129 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 35-21 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

The model has simulated Jets vs. 49ers 10,000 times and the results are in. We can tell you the model is leaning Under on the total. It's also generated a spread pick that hits more than 60% of the time!

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