Light middleweight champions Jermell Charlo and Brian Castano will fight Saturday in a 12-round boxing main event for the unified division titles. Charlo (34-1-1, 18 KOs) holds the WBC, WBA and IBF versions of the belt, while Castano (17-0-2, 12 KOs) holds the WBO title.

They fought last year to a split draw and the rematch takes place at Dignity Health Sports Park in Carson, Calif. The main card is set to start at 9 p.m. ET on Showtime.

Charlo is a -220 favorite (risk $220 to win $100), while Castano is priced at +180 (risk $100 to win $170) in the latest Caesars Sportsbook boxing odds. The over-under for total rounds completed is 10.5, with the over favored at -270 and the under priced at +205. 

Before settling any Charlo vs. Castano 2 picks of your own, make sure you see the boxing predictions and betting advice from SportsLine combat sports analyst Brandon Wise.  

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing analyst. Last November, he accurately called a stoppage between rounds No. 10 and 12 for Canelo Alvarez against Caleb Plant in their super middleweight unification bout. The proposition selection paid +450 and Wise also correctly called the fight to go over 9.5 rounds (-125) as Alvarez stopped Plant in Round 11. His strong 2021 boxing record also included calling Jamel Herring (+105) to upset Carl Frampton (-125) in April. Anyone who has followed Wise's combat sports picks is WAY UP! 

With Saturday's showdown fast approaching, Wise has studied Charlo vs. Castano 2 from every angle, identified the best value in the boxing odds and released his confident picks. 

We can tell you he likes the Over 10.5 rounds and he's also locked a STRONG money-line pick and two plus-money props, including one that returns 3-1! You ABSOLUTELY need to see Wise's picks before making any of your own!

Who wins Jermell Charlo vs. Brian Castano 2 on Saturday? And which outcome prop is a MUST-BACK? ... Join SportsLine here to see which bets you need to make for Saturday's big fight, all from the accomplished combat sports analyst who has been profitable every year!