The Week 18 NFL schedule features an AFC South rivalry game with the Indianapolis Colts set to host the Jacksonville Jaguars on Sunday. Indianapolis is 7-9 overall and 4-3 at home, while Jacksonville is 4-12 overall and 1-7 on the road. Both teams have been eliminated from postseason contention, but will be looking to close out their seasons on a high note. The Jags are looking to build off their 20-13 win over the Tennessee Titans, while the Colts are looking to bounce back from their 45-33 loss to the New York Giants.

Kickoff is set for 1 p.m. ET on Sunday at Lucas Oil Stadium. The Colts are favored by 3.5 points in the latest Colts vs. Jaguars odds, and the over/under is 44.5 points per SportsLine consensus. 

Before entering any Jaguars vs. Colts picks, you'll want to see the NFL predictions and betting advice from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 of the 2024 NFL season on a 30-14 hot streak on top-rated NFL picks this year -- a stunning 68% success rate! Longer term, it is on a 210-142 roll on top-rated NFL picks that dates back to the 2017 season and a 64-35 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen STRONG returns!

The model has simulated Jaguars vs. Colts 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that hits in 60% of computer simulations. You can only see the model's pick at SportsLine.

So who wins Colts vs. Jaguars, and which side of the spread hits in 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.