The Jacksonville Jaguars (0-4) host the Indianapolis Colts (2-2) in an NFL Week 5 AFC South battle on CBS and Paramount+. Kickoff from TIAA Bank Field in Jacksonville is set for 1 p.m. ET. The Jaguars are 3.5-point favorites in the latest Jaguars vs. Colts odds via SportsLine consensus, and the over/under for total points scored is 45. You may be able to stream Sunday's game live on Paramount+, which you can now try free for the first seven days when you sign up here.

Paramount+ is the only place to watch every minute of every NFL on CBS game this season. A subscription also gives you access to other sports content including the UEFA Champions League and Europa League, NWSL, Serie A, and countless movies and shows. You can now get a free 7-day trial, so sign up right here.     

Before making any Jaguars vs. Colts picks or any other NFL predictions, you NEED to see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2024 NFL season on an incredible 188-131 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 42-23 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Jaguars vs. Colts 10,000 times and the results are in. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in your own picks. And don't forget you may be able to stream the game on Paramount+ on ANY DEVICE!

Who wins Colts vs. Jaguars, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Colts vs. Jaguars spread is a MUST-BACK, all from the model on a 188-131 roll on NFL picks!