The Ohio Bobcats and Jacksonville State Gamecocks will play under interim coaches when they meet in the Cure Bowl on Friday afternoon in Orlando. Jacksonville State won its first Conference USA championship in just its second year in FBS football, but it will move forward without head coach Rich Rodriguez. Ohio is in the same position, as coach Tim Albin left for the same job at Charlotte. 

Kickoff is set for noon ET on Friday at Camping World Stadium. Ohio is favored by 6 points in the latest Jacksonville State vs. Ohio odds, while the over/under is 57.5 points per SportsLine consensus. Before entering any Ohio vs. Jacksonville State picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it went a profitable 43-34 on top-rated picks during the 2024 regular season. Anyone following at sportsbooks and on betting apps has seen impressive returns.

The model has simulated Jacksonville State vs. Ohio 10,000 times and the results are in. We can tell you that the model is leaning Under the total, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. 

So who wins Jacksonville State vs. Ohio? And which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!