The latest edition of one of college football's most storied rivalries renews on Saturday afternoon when the Iowa Hawkeyes host the Iowa State Cyclones. The first meeting took place in 1894 and Saturday's edition will be the 71st meeting in series history. The Hawkeyes have dominated this rivalry in recent years, winning seven of the past eight meetings with the Cyclones. 

Kickoff is scheduled for 3:30 p.m. ET. The Hawkeyes are 2.5-point favorites in the latest Iowa vs. Iowa State odds, while the over/under for total points scored is 36. Saturday's showdown can be seen live on CBS and streamed live on Paramount+. (See up-to-date odds for every game this week on our college football odds page.)

Before making any Iowa State vs. Iowa picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

The model knows that the Hawkeyes have piled up a ton of wins under head coach Kirk Ferentz. Iowa has eight seasons with 10+ wins with Ferentz at the helm, including three of the past five. A dominant defense is a big reason for that success and that was on full display in Iowa's season-opening win against Illinois State. Iowa's defense recorded a shutout in its 40-0 victory last week, its fourth shutout win since 2022.

The model also knows that Iowa State quarterback Rocco Becht started all 13 games for Iowa State last season and was named Big 12 Offensive Freshman of the Year. He threw for 3,120 yards last season, the fourth-most passing yards in the Big 12. He finished the year with 23 touchdown passes, which was the second-most in Iowa State history (2019 Brock Purdy). 

For Saturday, the model has set its sights on Iowa vs. Iowa State. We can tell you it is leaning Under the total, projecting 31 combined points. It also says one side of the spread hits more than 50% of the time! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Iowa vs. Iowa State, and which side of the spread hits more than 50% of the time? ... Join SportsLine right now to find out which side of the Iowa State vs. Iowa spread you should be all over Saturday, all from the model on a roll on college football picks.