Caitlin Clark will try to lead No. 1 seed Iowa on another deep run in the Women's NCAA Tournament when the Hawkeyes host No. 16 seed Holy Cross on Saturday afternoon. Iowa enters March Madness with a 29-4 record, rattling off six consecutive wins to generate momentum heading into the tournament. Clark helped the Hawkeyes erase an eight-point deficit with less than three minutes remaining in regulation against Nebraska in the Big Ten Tournament title game. Holy Cross advanced to the first round when it cruised to a 72-45 win over No. 16 seed UT Martin in the First Four on Thursday night. 

Tipoff is set for 3 p.m. ET. The Hawkeyes are 38.5-point favorites in the latest Iowa vs. Holy Cross odds, while the over/under is 157.5. Before you lock in any Holy Cross vs. Iowa picks or predictions, you have to see what women's basketball expert Calvin Wetzel has to say.

Wetzel, HerHoopStats.com lead betting writer, incorporates his mathematical background and strong knowledge of women's hoops to turn the site's prediction model into picks. Now Wetzel has turned his attention to women's college basketball after teaming up with Aaron Barzilai, a Ph.D. from Stanford.

Since the start of the 2021-22 women's college basketball campaign, Wetzel is 1,384-988 (+371.33 units)!

Wetzel knows that Iowa won its final three games of the regular season before rattling off three victories to win the Big Ten Tournament. The Hawkeyes are trying to finish off what they couldn't last season, as they fell to LSU in the national championship. Earlier this season, Caitlin Clark set the all-time Division I women's scoring record and the overall Division I record, which was formerly held by Pete Maravich. 

Wetzel also has taken into account that Holy Cross won the Patriot League Tournament last week, beating Boston University in the title game. The Crusaders advanced to the first round of the NCAA Tournament with a convincing 72-45 win over fellow 16-seed UT Martin in the First Four, as senior guard Cara McCormack scored a career-high 23 points. She knocked down seven 3-pointers on 10 attempts, and she had 18 points heading into halftime. 

Now, Wetzel has set his sights on Iowa vs. Holy Cross. We can tell you he is leaning Over the total, and he also has a strong play on the side along with a Caitlin Clark prop bet! You absolutely need to see what he says before locking in any women's college basketball picks.

So who wins Holy Cross vs. Iowa, and which Caitlin Clark prop bet should be targeting? Join SportsLine right now to find out which picks you should be all over for the NCAA Women's Tournament matchup, all from the expert who is up 371 units since the 2021-22 season!