Familiar foes face off as No. 1 Iowa Hawkeyes face the No. 5 Colorado Buffaloes in the NCAA women's basketball Sweet 16 on Saturday. Caitlin Clark and company defeated the Buffaloes as a No. 2 seed in last year's Sweet 16 en route to a national championship bid. This time around, the Hawkeyes just survived an upset attempt in the second round by West Virginia, while Colorado is rolling after a big 63-50 win against No. 4 Kansas State.

Tipoff is set for 3:30 p.m. ET. The Hawkeyes are 7.5-point favorites in the latest Iowa vs. Colorado odds, while the over/under is 157.5. Before you lock in any Iowa vs. Colorado picks or predictions, you have to see what women's basketball expert Calvin Wetzel has to say.

Wetzel, HerHoopStats.com lead betting writer, incorporates his mathematical background and strong knowledge of women's hoops to turn the site's prediction model into picks. Now Wetzel has turned his attention to women's college basketball after teaming up with Aaron Barzilai, a Ph.D. from Stanford.

Since the start of the 2021-22 women's college basketball campaign, Wetzel is 1,384-988 (+371.33 units)!

Wetzel knows that Colorado is arguably the hotter team heading into this matchup. Their difficult regular-season schedule toughened the Buffs, as big wins against conference foes like USC and Utah got them ready for a tournament run. They also have a balanced scoring attack when called upon, and six different players scored at least nine points in the second-round matchup against Kansas State. Colorado is a physical team that can apply a ton of pressure, which is something the Hawkeyes struggled with in their last game.

That being said, Iowa is still one of the best scoring teams in women's basketball. While the Mountaineers pressured them into 15 turnovers in the second round, the Hawkeyes have the tools to rebound in this Sweet 16 matchup. They were 0-for-17 from three-point range in their last game and are expected to right the ship on Saturday as they aim to get back to a national championship. Additionally, Clark scored half of Iowa's points in the second round and is expected to play the bulk of Saturday's game. 

Now, Wetzel has set his sights on Iowa vs. Colorado. We can tell you he is leaning Under the total, and he also has a strong play on the side along with a Caitlin Clark prop bet! You absolutely need to see what he says before locking in any women's college basketball picks.

So who wins Colorado vs. Iowa, and which Caitlin Clark prop bet should be targeting? Join SportsLine right now to find out which picks you should be all over for the NCAA Women's Tournament matchup, all from the expert who is up 371 units since the 2021-22 season!