A matchup between two top-25 teams headlines the Big 12 basketball schedule on Wednesday when No. 11 Iowa State hosts No. 25 Texas Tech at 9 p.m. ET. Red Raiders guard Terrence Shannon Jr. will miss the game with a back injury, and Tech will need to find a way to replace his 14.3 points per game. The Cyclones are coming off of their first win of the season against the defending national champions Baylor on New Year's Day.

The Cyclones are favored by four points in the latest Iowa State vs. Texas Tech odds from Caesars Sportsbook, and the over-under is set at 127. Before you make any Texas Tech vs. Iowa State picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Iowa State vs. Texas Tech 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 70 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Iowa State vs. Texas Tech? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks ... If you're already a member, see the picks below!