The No. 3 seed Iowa State Cyclones will try to punch their ticket to the Sweet 16 when they face the No. 6 seed Ole Miss Rebels in the second round of the NCAA Tournament on Sunday night. Iowa State is coming off a dominant first-round performance, cruising to an 82-55 win over No. 14 seed Lipscomb. Ole Miss was involved in one of the most exciting games during the first round, holding off a frantic comeback by No. 11 seed North Carolina.   

Tip-off from Fiserv Forum in Milwaukee is 7:45 p.m. ET. The Cyclones are 5.5-point favorites in the latest Ole Miss vs. Iowa State odds, via SportsLine consensus, while the over/under for total points is 144.5. The Cyclones are -240 money-line favorites. 

Before making any Ole Miss vs. Iowa State picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It entered the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Ole Miss vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in almost 60% of simulations!

So who wins Ole Miss vs. Iowa State, and which side of the spread hits in almost 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!