After losing six of its last eight games, Iowa State has won its last four, and looks to keep things going at home against Oklahoma State on Wednesday at 7 p.m. ET. Iowa State is 20-9 overall and 14-4 at home, while Oklahoma State is 13-15 overall but just 2-8 on the road. The Cowboys had won the last four games against the Cyclones prior to their last meeting on January 26, which Iowa State won, 84-81.

The Cyclones are favored by four points in the latest Iowa State vs. Oklahoma State odds from Caesars Sportsbook, and the over-under is set at 129. Before you make any Oklahoma State vs. Iowa State picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,700 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Iowa State vs. Oklahoma State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in just over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Iowa State vs. Oklahoma State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks ... If you're already a member, see the picks below!