The Big 12 and American Athletic Conference square off when the Iowa State Cyclones and Memphis Tigers collide in the 2023 AutoZone Liberty Bowl on Friday at Simmons Bank Liberty Stadium in Memphis. The Cyclones (7-5) tied for fourth in the Big 12. Meanwhile the Tigers (9-3) finished fourth in the AAC. 

Kickoff is set for 3:30 p.m. ET. The Cyclones are 10.5-point favorites in the latest Iowa State vs. Memphis odds, while the over/under for total points scored is 59. Before you make any Memphis vs. Iowa State picks or Liberty Bowl predictions, make sure you check out the analysis from SportsLine and CBS Sports expert Tom Fornelli, given his mastery of picks in games involving the Cyclones. 

A CBS Sports writer since 2010, the entertaining Fornelli is best known for his college football expertise. He co-hosts the popular Cover 3 Podcast and appears regularly on CBS Sports HQ. You'll get maximum access to Fornelli's picks only on SportsLine. What's more, he has demonstrated a particularly sharp eye for the Cyclones. In fact, Fornelli has gone 17-3 (+1370) on his last 20 picks in games involving Iowa State. Anyone who has followed him is way up.

Fornelli knows that the Cyclones have been winning the turnover battle all season. Utilizing a unique 3-3-5 defense, Iowa State has made 16 interceptions this season, which ranks eighth in the country. The Cyclones also have a +8 turnover margin, which is third in the Big 12 and 19th in the nation.

Fornelli also has taken into account that the Tigers are playing a de facto home game at Liberty Stadium. Since head coach Ryan Silverfield joined the Memphis staff in 2016, the Tigers have a record of 45-9 (83.3 winning percentage) at Liberty Stadium. Since 2014, they have 55 home wins, which ranks fifth in the nation, behind only Alabama (65), Clemson (65), Ohio State (61) and Georgia (56).

For Friday, Fornelli has studied the Iowa State vs. Memphis matchup from top to bottom and revealed his top selections for the Liberty Bowl. 

We can tell you he's leaning toward the Over on the posted total and has identified a critical X-factor makes one side of the spread a MUST-BACK. You ABSOLUTELY need to see what it is before locking in any Memphis vs. Iowa State picks of your own.

What side of the Iowa State vs. Memphis spread should you jump on? ... Join SportsLine right now to see the Memphis vs. Iowa State best bets from the expert who is 17-3 on his last 20 picks in games involving the Cyclones!