The No. 17 Iowa State Cyclones will take on the Iowa Hawkeyes at 9 p.m. ET Thursday at James H. Hilton Coliseum. The Cyclones are 8-0 overall and 5-0 at home, while Iowa is 7-2 overall and 1-1 on the road. Iowa State is ranked first in the Big 12; Iowa is ranked ninth in the Big Ten. 

The Hawkeyes are favored by 5.5 points in the latest Iowa State vs. Iowa odds from Caesars Sportsbook, and the over-under is set at 150.5. Before you make any Iowa vs. Iowa State picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Iowa State vs. Iowa 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Iowa State vs. Iowa? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!