The Week 13 college football schedule features a Big Ten matchup with significant College Football Playoff implications with the No. 2 Ohio State Buckeyes (9-1, 6-1) set to host the No. 5 Indiana Hoosiers (10-0, 7-0) on Saturday at Ohio Stadium. The Hoosiers are coming off a bye in Week 12 and defeated Michigan 20-15 in their last outing. The Buckeyes have won four straight after beating Northwestern 31-7 in their last game. Ohio State leads the all-time series 80-12-5. Indiana is 8-2 and Ohio State is 5-5 against the spread this season. 

Kickoff in Columbus, Ohio is at Noon ET. The Buckeyes are 10.5-point favorites in the latest Ohio State vs. Indiana odds via SportsLine consensus, while the over/under for total points scored is 52.5. Ohio State is a -429 (risk $429 to win $100) favorite on the money line, with Indiana listed as a +326 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Ohio State vs. Indiana picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, netting a whopping 66.92 units while posting a 208-132-6 record since Week 1 of the 2023 season. All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks is WAY UP!

Now, Kaylor has locked in a confident against-the-spread pick for Indiana vs. Ohio State in their Week 13 Big Ten matchup. We can tell you he's leaning Over on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Ohio State vs. Indiana in their Week 13 matchup in Columbus on Saturday, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 208-132-6, returning $6,692 for $100 bettors, betting on college football since Week 1 of the 2023 season, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates