The No. 18 Purdue Boilermakers will try to close the regular season on a three-game winning streak when they face the Illinois Fighting Illini on Friday night. Purdue lost four straight games in February, but it has bounced back with double-digit wins over UCLA and Rutgers. Illinois is coming off wins over Iowa and then-No. 15 Michigan, moving into a tie with Oregon for seventh place in the Big Ten. 

Tip-off is set for 8 p.m. on Friday at the State Farm Center. Illinois is favored by 4.5 points in the latest Illinois vs. Purdue odds, while the over/under is 158.5 points, per SportsLine consensus. Before entering any Purdue vs. Illinois picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 18 of the 2024-25 season on a 221-162 betting roll (+1895) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen HUGE returns.

The model has simulated Purdue vs. Illinois 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

So who wins Purdue vs. Illinois, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!