Illinois (2-5) and No. 7 Penn State (5-1) meet Saturday afternoon for a Big Ten matchup. The Nittany Lions should be rejuvenated as they return from their bye week. In Week 6, Penn State dropped their first game of the year and lost 23-20 to No. 11 Iowa. The Fighting Illini are also fresh off their bye week. Illinois has struggled through the first seven games, including a 24-0 shutout loss to Wisconsin on Oct. 9. 

Kickoff from Beaver Stadium is set for noon ET. The Nittany Lions are favored by 24 points in the latest Illinois vs. Penn State odds from Caesars Sportsbook, while the Over-Under is set at 45.5. 

Before making any Illinois vs. Penn State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Illinois vs. Penn State 10,000 times and the results are in. We can tell you that the model is leaning under the total, and it's also generated a point-spread pick that hits in almost 60 percent of simulations. You absolutely need to see it before locking in your own picks!

So who wins Illinois vs. Penn State? And which side of the spread hits almost 60 percent of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.