The Houston Cougars and Purdue Boilermakers are set to battle it out in the Sweet 16 round of the 2025 NCAA Tournament Friday. Houston advanced to the Sweet 16 by defeating SIUE 78-40 in the first round and Gonzaga 81-76 in the second round. Purdue beat High Point 75-63, then followed up with a 76-62 win over McNeese in the second round. Houston is 19-17 and Purdue is 19-16 against the spread this season.

Tipoff from Lucas Oil Stadium in Indianapolis is set for 10:09 p.m. ET. The Cougars are 8.5-point favorites in the latest Purdue vs. Houston odds from SportsLine consensus, while the over/under for total points scored is 134.5. 

Before making any Houston vs. Purdue picks, you'll want to check out the college basketball predictions from red-hot college basketball expert Micah Roberts.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. Over the past three college basketball seasons, Roberts is 267-227, returning $1,578 to $100 players.

Roberts enters the Sweet 16 of the 2025 NCAA Tournament on a 15-4-1 roll (+1042) over his last 20 college basketball picks involving Houston. Anybody who's followed his picks could be WAY UP!

For Houston vs. Purdue, Roberts is leaning Under on the point total, and he also found a critical x-factor that has has him jumping on one side of the spread. You ABSOLUTELY NEED to see these picks before locking in any 2025 NCAA Tournament picks of your own.

So who wins Houston vs. Purdue, and which side of the spread should you be backing on Friday? Join SportsLine right now to see which side of the spread you need to jump on, all from a red-hot college basketball expert that is on a 15-4 (+1042) run on his CBB picks involving Houston, and find out.