The No. 1 seed Houston Cougars (31-4) will match up with the No. 8 Gonzaga Bulldogs (26-8) on Saturday with a spot in the Sweet 16 of the NCAA Tournament 2025 on the line. This second-round matchup in the Midwest Region of March Madness pits the two teams with the longest active Sweet 16 streaks against one another. The Zags have made nine straight appearances in the round, while the Coogs have made five straight. Houston enters on a 14-game win streak, while Gonzaga has won five in a row.

Tip-off from the Intrust Bank Arena in Wichita, Kansas, is at 8:40 p.m. ET. The Cougars are 5.5-point favorites in the latest Gonzaga vs. Houston odds via SportsLine consensus, while the over/under for total points is 140.5.

Before making any Houston vs. Gonzaga picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated Gonzaga vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread cashes in well over 50% of simulations!

So who wins Houston vs. Gonzaga, and which side of the spread cashes in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!