Teams with long winning streaks face off when the Houston Cougars meet the Duke Blue Devils in an NCAA Tournament Final Four matchup on Saturday night. The Cougars (34-4), who have won 17 in a row, are seeking their first national championship and are making their seventh Final Four appearance. The Blue Devils (35-3), who have won 15 consecutive games, are seeking their sixth national title and have made their 18th Final Four.

Tipoff from the Alamodome in San Antonio is set for 8:49 p.m. ET on CBS. Duke is a 4.5-point favorite in the latest Houston vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 136.5. 

Before making any Houston vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 229-169 roll (+1805) on all top-rated college basketball picks dating back to 2023.  This model also ranks in the 99.5th percentile in a major bracket contest after correctly calling every Elite Eight and Final Four team this year. Anyone following could have seen HUGE returns!

The model has simulated Houston vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Houston vs. Duke, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 229-169 (+1805) on top-rated college basketball pick and has nailed 25 first-round upsets by double-digit seeds!