No. 17 BYU and No. 2 Houston are set to clash in a Big 12 Tournament 2025 semifinal matchup on Friday. Houston (28-4) is the tourney's top seed and is 19-1 in conference play, while BYU (24-8) is the 4-seed and is 14-6 in the Big 12. UH rolled 86-55 when these teams met in early January. This is each school's second year in the conference as they are both seeking their first Big 12 tournament titles. The winner will then face the victor of Arizona vs. Texas Tech in Saturday's championship game.

Tipoff is at 7 p.m. ET at the T-Mobile Center in Kansas City, Mo. UH is favored by 6.5 points in the latest BYU vs. Houston odds, per SportsLine consensus, and the over/under is 134 points. Houston is at -312 on the money line (risk $312 to win $100), with BYU listed at +249 (risk $100 to win $249). Before entering any Houston vs. BYU picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters conference championship week on a 225-165 roll (+1873) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated BYU vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Houston vs. BYU, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.