The No. 4 Houston Cougars will host the No. 11 Auburn Tigers in a battle between elite defensive teams on Saturday night. Houston opened the season with a 97-40 win over Jackson State on Monday, while Auburn is coming off a 94-43 win over Vermont. The Tigers had to initially return their plane to the airport following a fight between players that occurred after taking off on Friday night, but they were able to take another flight out of Alabama later in the evening. 

Tipoff is set for 9:30 p.m. ET on Saturday at Toyota Center. Houston is favored by 5.5 points in the latest Houston vs. Auburn odds, while the over/under is 141.5 points, per SportsLine consensus. Before entering any Auburn vs. Houston picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters the 2024-25 season on a 153-110 roll (+1891) on all top-rated college basketball picks dating back to 2023. Anyone following has seen huge returns.

The model has simulated Houston vs. Auburn 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Houston vs. Auburn? And which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.