The 13th-seeded High Point Panthers battle the fourth-seeded Purdue Boilermakers in a Midwest Regional first-round matchup on Thursday afternoon. The Panthers (29-5), who finished 14-2 in the Big South, are making their first trip to the NCAA Tournament. The Boilermakers (22-11), who finished tied for fourth in the Big Ten at 13-7, are making their 10th consecutive NCAA Tournament appearance and 36th overall.

Tipoff from Amica Mutual Pavilion in Providence, R.I., is set for 12:40 p.m. ET. Purdue is an 8-point favorite in the latest High Point vs. Purdue odds from SportsLine consensus, while the over/under for total points scored is 152.5.

Before making any High Point vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated High Point vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread cashes in well over 60% of simulations!

So who wins High Point vs. Purdue, and which side of the spread cashes in well over 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!