The New York Giants look to bounce back from an ugly 40-0 home drubbing to the Dallas Cowboys in Week 1 as they travel to the desert to take on the Arizona Cardinals on Sunday. The Cardinals fought valiantly but came up short on the road, 20-16 to the Washington Commanders. The teams most recently played in 2020, a 26-7 Cardinals road win. 

Kickoff from State Farm Stadium in Glendale, AZ is scheduled for 4:05 p.m. ET. The Giants are listed as a 4-point favorite and the over/under for total points scored is 39.5 points in the latest Giants vs. Cardinals odds.

Before making any Giants vs. Cardinals picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2023 NFL season on an incredible 163-114 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-7 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, the model has set its sights on Cardinals vs. Giants. We can tell you the model is leaning Over on the point total, and it also says one side of the spread cashes in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Giants vs. Cardinals in Week 2 of the 2023 NFL season, and which side of the spread cashes well over 50% of the time? Join SportsLine right now to find out which side of the Cardinals vs. Giants spread is a MUST-BACK, all from the model on a 163-114 roll on NFL picks!