The New York Giants and Buffalo Bills will meet on Sunday Night Football in Week 6. Giants quarterback Daniel Jones is out with a neck injury. Kickoff from Buffalo is set for 8:20 p.m. ET. For this game, SportsLine consensus lists the Bills as 15-point favorites, while the over/under is 43.5. Before you make any Giants vs. Bills picks or any other NFL predictions, you NEED to see which side SportsLine expert R.J. White is on. 

White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and went 535-450-30 on his ATS picks from 2017-22, which returned more than $3,500 to $100 players. He also closed the 2022 NFL season on an incredible 107-80-6 run on his last 193 against-the-spread and total NFL picks, returning more than $1,800 for $100 bettors.

Moreover, White has a read on the pulse of the Giants. He is an amazing 42-22 on his last 64 picks in games involving New York! Anyone who has followed him is way up. 

White knows the Bills lost All-Pro linebacker Matt Milano indefinitely due to an injury suffered in Week 5,and allowed 474 yards a week ago. Buffalo is also No. 25 or worse in the NFL in yards per play allowed (5.7), rushing yards allowed (134.0 per game), and yards allowed per rush attempt (5.8).

White also knows the Bills have a high-powered offense. Buffalo is averaging 31.8 points per game, including 35.8 in the last four outings. The Bills are scoring on 50% of offensive possessions this season, landing in the top four of the NFL in total yards, yards per play, red zone efficiency, third down efficiency, and passing yards.

Now, White has locked in another confident against the spread pick for Giants vs. Bills. We can tell you he's leaning Over the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Giants vs. Bills on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Giants vs. Bills spread to jump on, all from the expert who's an outstanding 44-22 on Giants picks!