We've reached the Sweet 16 in the 2025 NCAA Tournament and there's a high-profile Big Ten vs. SEC matchup in one of the West Region semifinals. No. 1 seed Florida will take on No. 4 seed Maryland on Thursday in San Francisco and both programs are hoping to take a step toward ending a Final Four drought, with Florida not making the national semifinals since 2014 and Maryland shut out since winning it all in 2002.

Tip-off from the Chase Center is set for 7:39 p.m. ET. Florida is a 6.5-point favorite in the latest Maryland vs. Florida odds from SportsLine consensus, while the over/under for total points scored is 156.5. The Gators are -312 money-line favorites. Before making any Maryland vs. Florida picks, you won't want to miss the college basketball predictions from red-hot college basketball expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been betting -- and winning -- for more than 30 years. 

He's done well in college basketball, going 341-208 (62.1%) over the last three campaigns. He joined SportsLine in 2024 and promptly went 28-14-1 (67%) in college basketball picks, returning $1,215 to $100 players. He's now 60-36 (+1828) in his last 96 official college basketball plays on SportsLine. Anybody who's followed his advice is WAY UP!

For Maryland vs. Florida, Casale is leaning Over on the total and he also found a critical x-factor that has has him jumping on one side of the spread. You ABSOLUTELY NEED to see these picks before locking in any 2025 NCAA Tournament picks of your own.

So who wins Maryland vs. Florida and which side of the spread should you back? Join SportsLine right now to see which side of the spread you need to jump on, all from a red-hot college basketball expert that is on a 60-36 (+1828) run on his NCAA hoops picks!