The Florida Gators and Houston Cougars square off in the NCAA Tournament National Championship Game on Monday, marking the final matchup of the 2025 NCAA Tournament. Monday's showdown marks the first time since 2008 that No. 1 seeds have met in the title game. The Gators knocked off Auburn 79-73 on Saturday, while Houston used a second-half surge to beat Duke 70-67. Florida has won two national titles (2006-07), while Houston is looking to claim its first national championship in program history. 

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Tipoff from the Alamodome in San Antonio is set for 8:50 p.m. ET on CBS. The Gators are 1.5-point favorites in the latest Florida vs. Houston odds via SportsLine consensus, while the over/under for total points scored is 140.5. 

Before making any Florida vs. Houston picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters this matchup on a 229-169 roll (+1805) on all top-rated college basketball picks dating back to 2023. This model also correctly called every Elite Eight and Final Four team this year. Anyone following could have seen HUGE returns!

Now, the model has simulated Florida vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over the total, and it also says one side of the spread hits over 50% of the time!

So who wins Florida vs. Houston, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that called every Elite Eight team this year!

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