Several big names will be absent from Week 5 Fantasy football lineups with the Lions, Eagles, Chargers and Titans all on bye. This means players like Jalen Hurts, Jahmyr Gibbs, J.K. Dobbins and Amon-Ra St. Brown could leave gaping holes on Week 5 Fantasy football rosters. Players of this magnitude will shuffle the Week 5 Fantasy football rankings and could create difficult Fantasy football start/sit decisions, especially with players like Jonathan Taylor (ankle), Malik Nabers (concussion), George Kittle (ribs), Taysom Hill (ribs), Trey McBride (ribs), Evan Engram (hamstring), and Davante Adams (hamstring) also potentially sidelined with injury.

Before setting your Week 5 Fantasy football lineups for the 2024 NFL season, you NEED to see the Fantasy football rankings from SportsLine's advanced computer model. 

When it comes to ranking players, SportsLine's model beat human experts for the past several seasons, especially when there were big differences in ranking! That could literally be the difference between winning your league or going home empty-handed.

Now the model, which simulates every NFL game 10,000 times, has revealed its latest Week 5 Fantasy football positional rankings.

For Week 5, the model's top three running backs are Derrick Henry (Ravens), Jordan Mason (49ers) and Kyren Williams (Rams). Henry ran for 199 yards and a touchdown on 24 carries while securing all three of his targets for 10 yards and another score in Baltimore's win last week over the Bills. Mason continues to shine in San Francisco's offense, finishing with at least 100 rushing yards in three of his past four games, while Williams has already racked up five rushing touchdowns this season.

The model is also calling for a SHOCKING quarterback you aren't even thinking about to finish in the top 10 of its Fantasy football rankings! This pick could be the difference between winning BIG and going home with nothing. You ABSOLUTELY need to see who it is before locking in your lineups.

So who should you start and sit in Week 5? And which surprising quarterback could lead you to victory? ... Join SportsLine now to get Fantasy football rankings for every single position, and see which shocking QB comes out of nowhere to crack the top 10, all from the model that has out-performed experts big-time!