The No. 4 Duke Blue Devils will host the Pittsburgh Panthers in ACC action on Tuesday. Duke is 12-2 overall, including 4-0 in the ACC. Pittsburgh is 12-2 overall, including 3-0 in the ACC. The Blue Devils are coming off an 89-62 victory over SMU on Saturday for their eighth straight win. The Panthers are coming off an 83-68 win over Stanford on Saturday for their fifth straight win. Duke and Pittsburgh split their two matchups last season, which included the Panthers defeating the Blue Devils, 80-76, for their first victory at Cameron Indoor Stadium since 1979.

Tipoff is set for 7 p.m. ET on Tuesday from Cameron Indoor Stadium in Durham, N.C. Duke is favored by 14.5 points in the latest Pittsburgh vs. Duke odds, while the over/under is 143.5 points per SportsLine consensus. 

Before entering any Duke vs. Pittsburgh picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 10 of the 2024-25 season on a 189-130 roll (+2985) on all top-rated college basketball picks dating back to 2023. Anyone who has followed it could have seen huge returns.

The model has simulated Pittsburgh vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting almost 70% of the time.

So who wins Duke vs. Pittsburgh, and which side of the spread hits almost 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.