The No. 4 Duke Blue Devils will try to remain atop the ACC standings when they host the Notre Dame Fighting Irish on Saturday afternoon. Duke is riding a nine-game winning streak and has won its first five conference games, including a 76-47 win over Pittsburgh on Tuesday. Notre Dame is on a three-game losing skid following its 66-65 heartbreaking loss at NC State on Wednesday.   

Tipoff is set for noon ET on Saturday at Cameron Indoor Stadium. Duke is favored by 19.5 points in the latest Duke vs. Notre Dame odds, while the over/under is 135.5 points, per SportsLine consensus. Before entering any Notre Dame vs. Duke picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 10 of the 2024-25 season on a 189-130 betting roll (+2985) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated Duke vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

So who wins Duke vs. Notre Dame? And which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.