One of the best rivalries in sports takes place for the 153rd time when the North Carolina Tar Heels host the Duke Blue Devils on the final day of the ACC season on Saturday. North Carolina leads the rivalry, 85-67, all-time and the two historic basketball programs are 4-4 head-to-head since the start of the 2021-22 college basketball season. North Carolina is 20-11 overall, including 13-6 in the ACC. Meanwhile, No. 2 Duke is 27-3 overall, including 18-1 in the ACC. Duke defeated North Carolina, 87-70, at home in their first matchup of the season.

Tipoff is set for 6:30 p.m. ET on Saturday from the Dean E. Smith Center in Chapel Hill, N.C. Duke is favored by 10 points in the latest North Carolina vs. Duke odds, while the over/under is 157.5 points, per SportsLine consensus, down a point from the opener. 

Before entering any Duke vs. North Carolina picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 18 of the 2024-25 season on a 221-162 roll (+1895) on all top-rated college basketball picks dating back to 2023. Anyone following could have seen HUGE returns!

The model has simulated North Carolina vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits well over 50% of the time!

So who wins Duke vs. North Carolina, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!