No. 10 Duke will try to bounce back from its loss to Wake Forest when it hosts Louisville in an ACC battle. Tipoff is set for 7 p.m. ET on Wednesday at Cameron Indoor Stadium. Duke is favored by 20 points in the latest Duke vs. Louisville odds, while the over/under is 151.5 points, per SportsLine consensus. 

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The model has simulated Duke vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

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