The No. 3 Duke Blue Devils will try to extend their three-game winning streak when they face the Illinois Fighting Illini at Madison Square Garden on Saturday night. Duke holds a one-game lead over Clemson and Louisville atop the ACC standings as it takes a brief hiatus from league play. Illinois is in seventh place in the Big Ten and is hoping to snap a two-game losing streak.  

Tipoff is set for 8 p.m. ET on Saturday at Madison Square Garden in New York City. Duke is favored by 9.5 points in the latest Duke vs. Illinois odds, while the over/under is 157.5 points, per SportsLine consensus. Before entering any Illinois vs. Duke picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 16 of the 2024-25 season on a 213-158 betting roll (+1675) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen HUGE returns.

The model has simulated Duke vs. Illinois 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations!

So who wins Duke vs. Illinois, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!