The two top teams in the AP Poll will meet in the 2025 Final Four on Saturday as the Duke Blue Devils (35-3) take on the Houston Cougars (34-4). Both teams are No. 1 seeds in the NCAA Tournament 2025, with Duke atop the top 25, while Houston is ranked No. 2 in the AP Poll. This 2025 March Madness contest is also a rematch of last year's Sweet 16 matchup in which Duke prevailed, 54-51, in their only previous meeting. The Blue Devils are seeking their first championship game appearance since winning it all in 2015, while the Cougars are looking for their first title game appearance since finishing as runner-up in 1984. 

Tipoff from the Alamodome in San Antonio is set for 8:49 p.m. ET on CBS. The Blue Devils are 4.5-point favorites in the latest Houston vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 136.5. 

Before making any Houston vs. Duke picks, you'll want to check out the college basketball predictions from red-hot college basketball expert Micah Roberts.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos' book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. Over the past three college basketball seasons, Roberts is 267-227, returning $1,578 to $100 players.

Roberts enters the Final Four of the 2025 NCAA Tournament on a 16-5-1 roll (+1017) over his last 22 college basketball picks involving Houston. Anybody who's followed his picks could be WAY UP!

For Houston vs. Duke, Roberts is leaning Under on the point total, and he also found a critical x-factor that has him jumping on one side of the spread. You ABSOLUTELY NEED to see these picks before locking in any 2025 NCAA Tournament picks of your own.

So who wins Houston vs. Duke, and which side of the spread should you be backing on Saturday? Join SportsLine right now to see which side of the spread you need to jump on, all from a red-hot college basketball expert that is on a 16-5-1 (+1017) run on his CBB picks involving Houston, and find out.