The Charlotte 49ers will take on the Duke Blue Devils at 7 p.m. ET on Friday at Jerry Richardson Stadium on CBS Sports Network. The 49ers ended last year fourth in the East Division, while Duke ended up 13th in the Coastal Division. The Blue Devils are favored by 6.5 points in the latest Charlotte vs. Duke odds from Caesars Sportsbook, and the over-under is set at 60.5. 

Before making any Duke vs. Charlotte picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Charlotte vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Charlotte vs. Duke? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks. .. If you're already a member, see the picks below!